Endogenous near-infrared chemiluminescent manganese ion-driven porphyrin supramolecular platform for the theranostics of thrombosis and ischemic stroke.

Authors

Nan Xiao, Yanqin Fan, Liping Zhang, Gelin Xu, Qian Zhang, Feng Chi, Yachao Wang, Pengcheng Fu, Yuqi Liao, Kaijia Lin, Ziwei Wang, Haixing Feng, Yanlei Li, Xin Zheng, Dongxia Zhu, Liming Cao, Lijie Ren

Published in

RSC advances. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

Ischemic stroke (IS) is a cerebrovascular disease with high mortality and disability rates. Effective treatment of IS remains limited by insufficient lesion identification, incomplete thrombus elimination, and progressively aggravated reperfusion injury, thus highlighting the urgent need for an integrated strategy that bridges precise imaging, efficient thrombolysis, and neuroprotection. This study developed a nanoplatform (Mn-Ce6@R NPs) through a simple one-pot coordination-driven self-assembly process, featuring facile preparation and good reproducibility. The coordination of Mn²⁺ modulated the aggregation state and photophysical behaviour of Ce6, thereby enhancing its ONOO^--responsive near-infrared chemiluminescence output and enabling precise imaging of thrombotic lesions and cerebral ischemia/reperfusion sites with a tissue penetration depth >10 mm. Under 689 nm laser irradiation, this platform synergistically triggered photothermal and photodynamic effects to achieve efficient thrombolysis. Meanwhile, its Mn-related enzyme-mimetic activity continuously scavenged RONS, alleviated inflammation, and exerted neuroprotective effects. The resulting nanoplatform exhibited excellent stability and high Ce6 loading capacity, with an approximately 77-fold enhancement in chemiluminescence signal toward ONOO^-. It also achieved an in vitro thrombolysis efficiency of 74.0% and significantly restored blood perfusion in vivo, while reducing cerebral infarct volume. Collectively, this study establishes a sequential nanotheranostic strategy for the continuous pathological progression of IS and provides a translationally promising approach for real-time monitoring, precise thrombolysis, and post-reperfusion protection.

PMID:
42405149
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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