Factors associated with medication adherence and perceived treatment barriers among Nepali women with polyendocrine metabolic ovarian syndrome: A cross- sectional study.

Authors

Sajana Basnet, Nirmal Raj Marasine, Shishir Paudel, Poonam Pant, Sabina Sankhi

Published in

Journal of public health research. Volume 15. Issue 3. Pages 22799036261465332. Epub Jul 03, 2026.

Abstract

Effective management of Polyendocrine Metabolic Ovarian Syndrome (PMOS) depends on sustained medication adherence, yet evidence on adherence patterns and treatment barriers in low-resource settings remains limited.
This study assessed factors associated with medication adherence and perceived treatment barriers among Nepalese women with PMOS.
Cross-sectional study.
A total of 145 women aged 18-49 years diagnosed with PMOS at an infertility center in Kathmandu were enrolled between December 2023 and May 2024. Data were collected via face-to-face interviews using the General Medication Adherence Scale (GMAS) and a Barriers Assessment Questionnaire. Chi-square tests and unadjusted odds ratios (uOR) with 95% confidence intervals (CI) identified associations.
Suboptimal adherence was observed in 66.3% of participants and 65.5% reported high treatment barriers. The factors associated withsuboptimal adherence included never-married status (uOR: 4.01; 95% CI: 1.87-8.43), lower educational attainment (illiterate: uOR: 1.40; 95% CI: 1.02-4.46; primary level: uOR: 1.38; 95% CI: 1.12-5.22), homemaker (uOR: 0.61; 95% CI: 0.29-0.88) or unemployed status (uOR: 0.91; 95% CI: 0.28-0.98), residence outside Kathmandu Valley (uOR: 0.95; 95% CI: 0.48-0.98), and smoking (uOR: 10.8; 95% CI: 1.23-95.2). High barriers were more likely among homemakers (uOR: 1.33; 95% CI: 1.13-2.80) and those outside Kathmandu Valley (uOR: 2.49; 95% CI: 1.21-5.14). Limited resources (p=0.028) and perceived symptomatic relief (p=0.011) were significantly associated with adherence.
Medication adherence was suboptimal, with barriers shaped by sociodemographic and healthcare access factors. Targeted interventions, rural outreach, patient education, and improved resource availability are essential to optimize PMOS treatment outcomes.

PMID:
42404444
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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