Baboon Syndrome Triggered by Diclofenac Potassium: A Case Report of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.

Authors

Abdalwahab AlKanderi, Alsadat Mosbeh, Abeer A AlBazali, Ashok K Sharma

Published in

Case reports in dermatology. Volume 18. Issue 1. Pages 372-379. Epub May 08, 2026.

Abstract

Baboon syndrome, also known as symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), is a rare reaction characterised by distinct, bilateral erythema in the flexural and intertriginous regions, occurring without systemic symptoms.
We present a 53-year-old gentleman who, 3 days after commencing diclofenac potassium for knee pain, exhibited symmetrical, well-defined erythema affecting the neck, axillae, cubital and popliteal fossae, forearms, inguinal folds, thighs, legs, and feet. He displayed no systemic symptoms or fever. The time and distinctive distribution of SDRIFE induced by diclofenac potassium were congruent.
Following the cessation of diclofenac potassium, the patient received topical corticosteroids and oral antihistamines. The symptoms resolved after 1 week.
This case highlights the necessity for physicians to identify this presentation for prompt diagnosis and care and also indicates diclofenac potassium as a possible cause of SDRIFE.

PMID:
42405225
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.