Novel Endoscopic Closure of Iatrogenic Hypopharyngeal Perforations Using Through-the-Scope Tissue Approximation Clips.

Authors

Pranav Ramamurthy, Kais Zakharia

Published in

ACG case reports journal. Volume 13. Issue 7. Pages e02215. Epub Jul 03, 2026.

Abstract

Hypopharyngeal perforation is a rare but potentially life-threatening complication of upper aerodigestive tract instrumentation. Management strategies remain controversial, and data supporting flexible endoscopic closure in this region are limited. We describe 3 cases of iatrogenic hypopharyngeal perforations successfully managed with MANTIS through-the-scope tissue approximation clips as part of a multidisciplinary approach. All defects were closed endoscopically. Two patients achieved complete mucosal healing without surgical intervention. One patient experienced clinical decline related to comorbid illness rather than closure failure. Endoscopic closure using through-the-scope clips may be a feasible option in carefully selected patients when performed early with multidisciplinary collaboration.

PMID:
42405295
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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