Life-Threatening Variceal Bleeding in Antisynthetase Syndrome: Nodular Regenerative Hyperplasia and Porto-Sinusoidal Vascular Disorder.

Authors

Jazmin Mexia Cabrales, Hassan Sinan, Bibhuti Adhikari, Harleen Sidhu, Anastasia Novikov, Aaron Walfish

Published in

ACG case reports journal. Volume 13. Issue 7. Pages e02226. Epub Jul 03, 2026.

Abstract

Antisynthetase syndrome (ASyS) is an autoimmune disorder that may be associated with hepatic involvement, such as nodular regenerative hyperplasia (NRH), a histologic manifestation of porto-sinusoidal vascular disorder, and complications such as variceal bleeding despite preserved liver function. We report a case of life-threatening variceal hemorrhage due to NRH-associated porto-sinusoidal vascular disorder in a patient with ASyS. This case highlights NRH as a cause of severe gastrointestinal bleeding in ASyS and underscores the need for diagnostic and management strategies distinct from those used in cirrhosis.

PMID:
42405292
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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