Marked response to immunochemotherapy in airway mucosal recurrence of lung squamous cell carcinoma.

Authors

Zijian Li, Chudong Wang, YenZhir Tay, Shuben Li

Published in

Interdisciplinary cardiovascular and thoracic surgery. Jul 06, 2026. Epub Jul 06, 2026.

Abstract

Airway mucosal recurrence after complete resection of primary lung cancer is rare and lacks standard treatment. We report a case of a 50-year-old male patient who underwent right upper sleeve lobectomy for lung squamous cell carcinoma(pT1bN0M0). He presented to us with an irritative cough 2 years later. Computed tomography and bronchoscopy revealed multiple recurrent polypoidal lesions in the trachea, with biopsy confirming recurrent squamous cell carcinoma. After restaging and multidisciplinary evaluation, the patient was offered immunochemotherapy. The recurrent mucosal lesions exhibited a favourable response to the combination of a PD-1 inhibitor and chemotherapy, suggesting a potentially effective strategy for high-risk patients.

PMID:
42406420
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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