Friend or foe? IFNλ drives fibrosis.

Authors

Ivan Zanoni

Published in

The Journal of experimental medicine. Volume 223. Issue 8. Aug 03, 2026. Epub Jul 06, 2026.

Abstract

Type III IFNs, or IFNλ, are pleiotropic immune mediators that mostly work at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang, and colleagues (https://doi.org/10.1084/jem.20251858) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal fibrosis.

PMID:
42405953
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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