Authors
Jiakui Wang, Pengxian Xie, Zhengqiang Kang
Published in
Quintessence international (Berlin, Germany : 1985). Volume 0. Issue 0. Pages 0. Jul 06, 2026. Epub Jul 06, 2026.
Abstract
To examine mortality trends and disparities in cancers of the lip, oral cavity, and pharynx (LOCP) among adults in the United States.
We analyzed underlying cause-of-death data (ICD-10 C00-C14) for LOCP cancers among adults aged ≥25 years from 1999 to 2023 using the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database. Age-adjusted mortality rates (AAMR) were standardized to the 2000 U.S. standard population. Joinpoint regression estimated annual percent change (APC) and average annual percent change (AAPC), and Autoregressive Integrated Moving Average models projected mortality through 2046.
From 1999 to 2023, 225,876 deaths were recorded. Overall AAMR declined until 2009 (APC: -1.28)* and then increased through 2023 (APC: 0.72)*. Males accounted for 69.6% of deaths, and adults aged 75-84 years showed the fastest recent increase (APC: 3.83)*. By 2023, Non-Hispanic (NH) White individuals had a higher AAMR than NH Black individuals (4.64 vs 3.51 per 100,000). Mortality increased in nonmetropolitan areas (AAPC: 0.53)* and the Midwest (AAPC: 0.56)*. State-level AAMR was highest in West Virginia and lowest in Utah. Projections suggest this burden will persist through 2046.
Mortality from LOCP cancers has shifted toward NH White individuals, older adults, nonmetropolitan populations, and the Midwest. These findings support targeted prevention, early detection, and referral strategies for high-burden groups.
PMID:
42405801
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.
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