Association of Race and Ethnicity with the Diagnosis and Management of Wolff-Parkinson-White Pattern in Children.

Authors

Mathew Hakimi, Ivor B Asztalos, Alexis Z Tomlinson, Antara Mondal, Ramesh V Iyer, Maully Shah, Chandra Srinivasan, Victoria L Vetter, Christopher Janson

Published in

Pediatric cardiology. Jul 06, 2026. Epub Jul 06, 2026.

Abstract

There are limited data on the impact of race/ethnicity on diagnosis/management of children with Wolff-Parkinson-White pattern (WPW). Investigate if detection of WPW by electrocardiogram (ECG) and risk stratification by exercise stress test (EST) and electrophysiology study (EPS) differ by race/ethnicity in children. We performed a retrospective cohort study of patients 0-21 years old, excluding those with congenital heart disease, using ECG, EST, and EPS databases at a children's hospital. The primary exposure was race/ethnicity. Outcomes were (1) detection of WPW pattern on ECG, (2) completion of EST, and/or (3) EPS. Likelihood and time to outcome were assessed with multivariable logistic regression and Cox regression, respectively, adjusted for birth year. Of 1,683,746 patients born between 1991 and 2021 and seen between 2010 and 2021, WPW pattern was detected in 898. Adjusting for birth year, Asian, Black, and Other race were associated with lower odds of WPW detection compared to White patients (OR 0.57, 0.66, 0.70; p ≤ 0.01). 616 WPW patients underwent EST, with Hispanic race having a lower odds of undergoing EST compared to White patients (OR 0.59; p ≤ 0.05). 739 WPW patients underwent EPS, with Black, Hispanic, and Other race having lower odds of EPS compared to White patients (OR 0.44, 0.53, 0.59; p ≤ 0.05). Non-White racial/ethnic groups had lower odds of ECG detection of WPW pattern. Among WPW patients, minority groups had lower odds of undergoing EST and EPS compared to White patients. Disparities may exist in referral or access to EST/EPS.

PMID:
42406065
Bibliographic data and abstract were imported from PubMed on 06 Jul 2026.

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