Mechanochemical Piezoelectric Catalysis: Advancing the Hydrogenation of Alkenes.

Authors

Zixi Ai, Mengting Liu, Xiaohong Wang, Xiaochun He, Xuemei Zhang, Zhong Lian

Published in

Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e76446. Jul 06, 2026. Epub Jul 06, 2026.

Abstract

Alkene hydrogenation reactions are essential processes widely utilized across diverse scientific fields for the production of pharmaceuticals, natural products, and various functional materials. Current strategies (e.g., metal hydrogen atom transfer [mHAT], photo/electrochemistry) consistently necessitate compromises, invariably involving transition metals, pressurized H₂, or solvent-intensive conditions. Herein, we report a mechanochemical hydrogenation reaction of both activated and unactivated alkenes via piezoelectric catalysis under conditions that are free from transition-metals, H₂ gas, and solvents. This approach exhibits good compatibility with various functional groups and demonstrates a broad substrate scope. In addition, the hydrogenation of bioactive molecule derivatives for modification purposes highlights its potential applications in the pharmaceutical industry. Based on mechanistic investigations, we propose a potential mechanism for the alkene hydrogenation via piezoelectric catalysis.

PMID:
42406538
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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