Authors
Dehao Chen, Prasanna Samuel, Rajan Srinivasan, Adrien Le Guillou, Venkata Raghava, Saad B Omer, Benjamin A Lopman, Samuel M Jenness
Published in
Epidemiology (Cambridge, Mass.). Jul 06, 2026. Epub Jul 06, 2026.
Abstract
The epidemic potential of infectious diseases depends on how contacts connect individuals over time-a form of temporal connectivity that has rarely been quantified in resource-poor settings. We used the forward-reachable path (FRP)-the proportion of population reachable from an index person via direct or indirect connections-to quantify temporal connectivity in contact networks relevant for acute respiratory transmission.
From empirical social-contact data collected in rural and urban Tamil Nadu, India, we derived contact-location-specific network statistics. These statistics were used to parameterize dynamic network models, simulate daily networks over one year, and compute FRPs.
In both rural and urban networks, mean FRPs rose sharply on day 1, then either increased steadily at school and work or plateaued at home and at locations included in the other layer (that is, locations other than home, school, and work). By day 365, mean FRPs followed the order: home (0.06% [rural] and 0.03% [urban]) < school (11.96% [rural] and 9.14% [urban]) < work (12.55% [rural] and 26.72% [urban]) < other (40.54% [rural] and 67.99% [urban]). The mean FRP peaked at home among those aged ≥60 years, at school among those aged 10-19 years, and at work among those aged 40-59 years.
Although FRP at home was bounded by household size, reachability expanded substantially through school, work, and other contacts. These findings indicate high temporal connectivity and substantial epidemic potential for acute respiratory transmission in these settings.
PMID:
42406882
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.
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