Authors
Xinyue Fu, Hao Chen, Meihang Du, Peiheng Li, Yue Zhao, Huanzuo Yang, Hancong Li, Gongshuang Zhang, Puxing He, Shuang Wu, Miao Zhang, Zhenmei An, Zhihui Li, Binwu Ying, Juan Rául Hernandez Silva, Liwei An, Han Luo
Published in
Chinese medical journal. Jul 03, 2026. Epub Jul 03, 2026.
Abstract
The rapid development of high-throughput sequencing technologies and bioinformatics has enabled the identification of diverse microbial communities within tumor tissues, giving rise to the concept of intratumoral microbiota. Comprising bacteria, viruses, fungi, and archaea, the intratumoral microbiota has been shown to play critical roles in tumor initiation, progression, and therapeutic responses. This review systematically summarizes the composition, ecological characteristics, and functional roles of intratumoral microbiota, with particular emphasis on its dual regulatory mechanisms in tumorigenesis, progression, metastasis, and recurrence. We further delineate four principal mechanistic pathways through which intratumoral microbiota influence tumor biology, including receptor-mediated signaling, metabolic reprogramming, effector molecule secretion, and intracellular invasion. Additionally, we evaluate the translational potential of these findings in clinical oncology, offering innovative perspectives for tumor diagnosis, therapeutic intervention, and preventive strategies.
PMID:
42409802
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 8
- Comments 0