Authors
Aparna Joshi, Richa Gupta, Anjali Aggarwal, Anand Kumar Mishra, Tulika Gupta, Justin Jacob, Vinit Sharma, Tsering Sangdup
Published in
Clinical anatomy (New York, N.Y.). Jul 07, 2026. Epub Jul 07, 2026.
Abstract
Age-related senescence can profoundly alter the physiology and therapeutic potential of cardiac progenitor cells (CPCs), thus undermining the efficiency of cell-based therapies for treatment of various cardiovascular diseases. In this study, CPCs were isolated from right atrial appendage tissue obtained during open heart surgery from patients: younger (< 30 years, n = 10) and elderly (> 60 years, n = 10). Phenotypic and functional characterization of CPCs was done along with evaluation of age-related senescent changes using various assays. CPCs derived from elderly patients exhibited significantly reduced proliferative potential, enlarged morphology, increased expression of senescence markers (p16Ink4A, SA β-gal, γH2AX), and significantly higher proportion of cells in the G0/G1 phase of the cell cycle. In addition, aged CPCs showed elevated secretion of senescence associated secretory phenotypes (SASP) factors, particularly IL-8, IL-10, and IFN-γ. Current study observed that a significantly higher (80%) number of CPCs among the older population were senescent, dysfunctional, and in the resting phase of the cell cycle, thus having limited ability to repair the damaged heart. Further, we observed a contradictory increase in Nkx2.5 expression with age, suggesting the reactivation of the cardiac Nkx2.5 enhancer.
PMID:
42411173
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.
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