Mechanistic and Therapeutic Approach of Plants as an Anti-inflammatory Agent: A Review.

Authors

Komal Raghuvanshi, Mehak Thakur, Disha Raghuvanshi, Dinesh Kumar, Rachna Verma, Kamil Kuca

Published in

Mini reviews in medicinal chemistry. Jul 03, 2026. Epub Jul 03, 2026.

Abstract

Chronic inflammation is a prolonged immune response that leads to the development of numerous diseases, including arthritis, cardiovascular disorders, and metabolic syndromes. Currently, synthetic anti-inflammatory medications are widely used to treat chronic inflammation due to their high efficacy. However, their long-term use is often associated with serious side effects. This led to an urgent need to explore the anti-inflammatory drugs that are more efficient and exhibit few or no adverse effects. Several studies have revealed the anti-inflammatory properties of various plants. However, most focus primarily on listing anti-inflammatory plants and their phytoconstituents, with limited scientific validation. In addition, no compiled data is available that includes comprehensive pre-clinical and clinically validated studies of anti-inflammatory plants and their phytoconstituents. The current study aims to provide a comprehensive overview of chronic inflammation and its management, addressing the challenges of synthetic anti-inflammatory medications, and investigating the potential of plants and their phytoconstituents as anti-inflammatory agents, with scientific validation through preclinical and clinical studies. Literature was searched, analyzed, and compiled from PubMed, ScienceDirect, and Google Scholar databases. The search terms used included anti-inflammatory plants, phytoconstituents, in-vitro and in-vivo, anti-inflammatory drugs, inflammation mechanism, etc., and several combinations of these keywords. A total of 297 publications published between August 1978 and February 2026 were included in this review. Overall, this review provides a detailed mechanistic explanation of plant-derived anti-inflammatory drugs for the treatment of chronic inflammation.

PMID:
42411092
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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