Light-triggered hydrogen cyanide (HCN) release from self-immolative cyanohydrin donors.

Authors

Ally N Stonas, Michael D Pluth

Published in

Chemical communications (Cambridge, England). Jul 07, 2026. Epub Jul 07, 2026.

Abstract

Hydrogen cyanide (HCN) is an emerging gasotransmitter and protic small molecule bioregulator. We report HCN release from a series of light-triggered, self-immolative cyanohydrin donors built on the 4,5-dimethoxy-o-nitrobenzyl (DMNB) platform. We demonstrate carbonate- and ether-ligated strategies for increasing release efficiency, expanding the chemical space for HCN release.

PMID:
42411342
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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