Effect of titanium-based anisotropic magnetic hydrogel coating on osseointegration.

Authors

Liu He, Jingxi Wang, Zengzilu Xia, Yuanda Chen, Hongli Luo, Fen Liu, Huiwen Zhang, Kaiyong Cai

Published in

Biomaterials science. Jul 07, 2026. Epub Jul 07, 2026.

Abstract

Titanium (Ti) implants suffer from elastic modulus mismatch with bone tissue, causing stress-shielding effects that lead to osteopenia and aseptic loosening. While hydrogel coatings have been explored to improve osseointegration, conventional hydrogels are limited by their isotropic structure and poor mechanical performance. Herein, we developed an anisotropic magnetic hydrogel coating on polydopamine-modified Ti surfaces by incorporating polydopamine-functionalized magnetic nanoparticles and calcium phosphate oligomers into gelatin methacryloyl matrices. The coating exhibited combined advantages of structural anisotropy, magnetic responsiveness and high mechanical strength, which facilitated BMSC adhesion and aligned orientation. Upon exposure to an external dynamic magnetic field, the stiffness of the hydrogel coating can be reversibly tuned. Both in vitro and in vivo results demonstrated that the anisotropic magnetic hydrogel coating significantly enhanced BMSC osteogenic differentiation and Ti implant osseointegration under dynamic mechanical stimulation. This study provides a new approach for designing smart orthopedic implants and establishes a basis for magnetically driven remote dynamic therapy.

PMID:
42411258
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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