Authors
Marjan Khan, Sohawm Sengupta, Puneet Bansal, Kue Tylor Lee, Asim Ahmed, Asif Iqbal, Agha Wali, Hritvik Jain, Israr Khan, Basil Rasool, Mumtaz Yaseen Balkhi, Muhammad Samsoor Zarak, Mahrukh Khan, Naga K Sucharita Cheedella, Muhammad Ahmad Nadeem, Cecille Nemeth, Amir Humza Sohail, Asad Ullah
Published in
Proceedings (Baylor University. Medical Center). Pages 1-9. Jul 07, 2026. Epub Jul 07, 2026.
Abstract
Signet ring cell carcinoma (SRCC), a rare subtype of colorectal adenocarcinoma, is associated with high rates of metastasis at presentation and poor prognosis. This study highlights demographic patterns, survival outcomes, and prognostic factors in young-onset SRCC.
A retrospective analysis of SRCC patients <50 years was conducted using the Surveillance, Epidemiology, and End Results database (2000-2020).
There was a high prevalence of SRCC in young patients, with a median age at diagnosis of 41.0 years. A significant proportion of cases were in individuals ages 36 to 50. The rectum was the most common primary site (29.1%), and the liver was the most frequent site of metastasis at presentation (8.9% of patients with known metastases). Surgery combined with adjuvant chemotherapy yielded the highest 5-year survival (24.4%; 95% confidence interval [CI], 22.1-26.7), compared with chemotherapy alone (2.6%; 95% CI, 1.2-4.0). Multivariate analysis identified advanced stage, nodal positivity, distant metastases (hazard ratio 7.02; 95% CI, 4.66-10.56), and larger tumor size as significant adverse prognostic factors (all P < 0.001).
Colorectal SRCC is an aggressive malignancy that disproportionately affects patients <50 years and frequently presents at advanced stages, underscoring the importance of earlier screening.
PMID:
42411783
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.
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