The causal associations of serum uric acid levels and gout with the risk of acute pancreatitis: A bidirectional Mendelian randomization study.

Authors

YiQing Lin, QianWen Zheng, LianGong Peng, Mo Chen, Chao Zhang, Shuifang Chen

Published in

Medicine. Volume 105. Issue 27. Pages e49605. Jul 03, 2026.

Abstract

This study investigates the causal links between serum uric acid (UA), gout, and the risk of acute pancreatitis (AP) using a bidirectional 2-sample Mendelian randomization analysis of genome-wide association studies data. The primary inverse variance weighted method indicated that genetically predicted higher serum UA levels are causally associated with an increased risk of AP (odds ratio [OR] = 1.194, 95% confidence interval [CI]: 1.020-1.399, P = .027). Conversely, the reverse Mendelian randomization analysis suggested a potential weak inverse association, with genetically predicted AP linked to slightly lower serum UA levels (OR = 0.989, 95% CI: 0.978-1.000, P = .043). Regarding gout, we found no statistically significant evidence to support a causal relationship in either direction: from gout to AP (OR = 0.015, 95% CI: 0.000-1.231, P = .062) or from AP to gout (OR = 1.001, 95% CI: 1.000-1.002, P = .217). These results support a causal role for elevated UA in AP pathogenesis, suggesting its relevance in risk assessment, while gout itself does not appear to be a causal factor for AP.

PMID:
42410834
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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