Authors
Jing Yang, Yao Lu, Yutao Zhang, Xiuyan Zhao, Xie Li, Chenxu Yan, Yuzheng Zhao, Wei-Hong Zhu, Zhiqian Guo
Published in
Angewandte Chemie (International ed. in English). Pages e3027612. Jul 07, 2026. Epub Jul 07, 2026.
Abstract
Endogenous chemiluminescence offers a transformative approach to photodynamic therapy that circumvents the limited penetration of external light and enables tumor-selective activation. However, most chemiluminescence-driven photodynamic therapy (CL-PDT) systems typically rely on intracellular oxidants (e.g., H2O2) as chemiexcitation "fuels", which conceptually contradicts the primary goal of elevating intratumoral oxidative stress. In this study, we report a sequential H2S-triggered redox relay nano-photosensitizer, NP-Rubine, which addresses the fundamental "redox paradox" by decoupling photon generation from oxidation consumption. Composed of an H2S-responsive chemiluminescent probe (Rubine) and a N-oxide scaffold (OPDEA-Ppa), NP-Rubine is selectively activated by endogenous H2S to initiate an efficiency chemiluminescence resonance energy transfer (CRET) cascade for efficient singlet oxygen (1O2) production. Concurrently, the N-oxide moiety promotes deep tumor penetration via transcytosis and depletes the intracellular NADPH pool. By synergistically coupling oxidant generation with reductant exhaustion, NP-Rubine synergistically amplifies intracellular redox imbalance to induce apoptosis. In vivo studies substantiate that NP-Rubine achieves exceptional deep-tissue imaging and potent antitumor efficacy in HCT116 xenografts. This bio-reductant, self-sustained targeted CL-PDT strategy circumvents the practical hurdles of oxidation-fueled systems, offering a robust benchmark for precision nanomedicine in complex redox landscapes.
PMID:
42412407
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.
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