Concise Synthesis of Pyrano/Benzopyrano[2,3-c]pyrazol-6-ones via Ir/Rh-Catalyzed C-H Activation and Tandem Annulation.

Authors

Miaomiao Chen, Wangcheng Hu, Wenran Ni, Zhiting Wang, Shuguang Chen, Yongjia Shang

Published in

The Journal of organic chemistry. Jul 07, 2026. Epub Jul 07, 2026.

Abstract

A general strategy for synthesizing pyrano/benzopyrano[2,3-c]pyrazol-6-ones has been developed through a C-H activation/cyclization tandem reaction from readily available N-hydroxyamides and diazopyrazolones. Broad substrate scope and excellent functional group tolerance highlight the versatility of this approach. The scalability of the reaction and the ability to perform diverse functional group transformations on the resulting benzopyrano[2,3-c]pyrazol-6-one derivatives further demonstrate its practical utility. Overall, this method overcomes the limitations of conventional synthetic routes, offering a general and efficient pathway for constructing this important class of compounds.

PMID:
42412400
Bibliographic data and abstract were imported from PubMed on 07 Jul 2026.

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