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Nematode-Killing Fungi: Model Systems for Fungal-Animal Interactions.

Created on 08 Jul 2026

Authors

Rebecca J Tay, Tzu-Hsiang Lin, Yi-Yun Lee, Yen-Ping Hsueh

Published in

Annual review of microbiology. Jul 07, 2026. Epub Jul 07, 2026.

Abstract

Predation is a powerful ecological and evolutionary force that shapes species interactions across the tree of life. Nematophagous fungi are specialized predators that use diverse strategies to capture and consume nematodes, Earth's most abundant animals. Two major groups of nematophagous fungi-nematode-trapping fungi and toxin-producing fungi, exemplified by Arthrobotrys oligospora and Pleurotus ostreatus, respectively-have emerged as tractable models for studying predator-prey interactions across spatial and temporal scales. Their interactions with the model nematode Caenorhabditis elegans provide insights into fundamental aspects of predation, including prey attraction, detection, and capture, while the genetic tools in C. elegans allow investigation into the prey's perspective. Additionally, studies of nematophagous fungi hold translational promise for the development of safe and sustainable biocontrol against parasitic nematodes. This review synthesizes our current knowledge of the ecology, evolution, and molecular predation mechanisms of nematode-trapping and toxin-producing fungi, highlighting these systems as invaluable models for predator-prey biology.

PMID:
42412997
Bibliographic data and abstract were imported from PubMed on 08 Jul 2026.

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