Authors
Chu Huang, Zongxian Li, Wei Shen, Meilin Luo, Faquan Lin
Published in
Frontiers in cellular and infection microbiology. Volume 16. Pages 1847110. Epub Jun 23, 2026.
Abstract
Biliary atresia (BA) is a progressive fibroinflammatory disease affecting both intrahepatic and extrahepatic bile ducts. It leads to cholestasis, hepatic fibrosis, and eventually biliary cirrhosis. Although BA is the most common cause of neonatal cholestasis, its exact pathogenesis remains incompletely understood. Emerging evidence suggests that disturbances in bile acid metabolism, gut microbiota dysbiosis, and vitamin D deficiency may play critical roles in the initiation and progression of BA. This review systematically summarizes the dynamic evolution characteristics of bile acid profiles, gut microbiota composition, and vitamin D levels in children with BA across different disease stages. It further explores the potential positive feedback loop effects of the bile acid-gut microbiota-vitamin D axis in the pathogenesis and progression of the disease. Additionally, this review discusses potential diagnostic value and therapeutic strategies based on this axis. Interventions targeting bile acid metabolism, modulating the gut microbiota, and supplementing vitamin D have shown promise in altering the disease course. Despite these advances, further research is needed to elucidate the precise molecular mechanisms underlying this axis in BA. Such knowledge will pave the way for more effective preventive and therapeutic strategies for this complex disease.
PMID:
42416276
Bibliographic data and abstract were imported from PubMed on 08 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 10
- Comments 0