Authors
Filippos Anagnostakis, Cliodhna Kate O'Toole, Guray Erus, Dhivya Srinivasan, Yuhan Cui, Michail Kokkorakis, Xin Ma, Christiane Reitz, Adam M Brickman, Despina Kontos, Ajay Gupta, Sam Payabvash, Elisa E Konofagou, Grace McIlvain, Feixiong Cheng, Matthew R Baldwin, Haochang Shou, Christos Davatzikos, Susan Resnick, Junhao Wen
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 7. Pages e71528.
Abstract
The association of sleep duration with Alzheimer's disease (AD) - related brain atrophy and cognition remains unclear.
Among 38,816 participants in the UK Biobank, we examined the association between sleep duration and a validated machine-learning-derived magnetic resonance imaging (MRI) signature of AD-related atrophy (Spatial Pattern of Abnormality for Recognition of Early AD [SPARE-AD]) and three cognitive test scores using generalized additive models. Independently, electronic health records (EHR) from TriNetX were used to examine the 10-year AD risk associated with insomnia and hypersomnia.
Sleep duration exhibited a U-shaped association with SPARE-AD (p = 0.001), Trail Making Tests A and B, and the Digit Symbol Substitution Test (all p < 0.001). Short (5-6 hours) and long (9-10 hours) sleep duration were associated with poorer cognitive performance. Both insomnia and hypersomnia showed a high risk for Alzheimer's disease.
This study demonstrates a U-shaped association between sleep duration and AD-like atrophy and cognition.
These findings show that excessive or insufficient sleep is linked to worse brain health.
PMID:
42417271
Bibliographic data and abstract were imported from PubMed on 08 Jul 2026.
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