Carbonylative Aminative Suzuki-Miyaura Coupling: Pd-Catalyzed Synthesis of Amides from Vinyl/Aryl Halides and Boronic Acids.

Authors

Jianhan Zhou, Dalton Raykowski, Zuzanna Kowalski, Shangyu Li, Yifan Ping, Yongrui Luo, Eugene E Kwan, Richard Y Liu

Published in

Journal of the American Chemical Society. Jul 08, 2026. Epub Jul 08, 2026.

Abstract

Amide synthesis is critical for the development of pharmaceuticals, agrochemicals, and functional materials. Here, we report a four-component variant of the Pd-catalyzed Suzuki-Miyaura coupling that repurposes partners conventionally used for C-C bond formation to instead yield amides. The sequential insertion of CO, from Mo(CO)₆ as a convenient surrogate, and NH, from O-(diphenylphosphinyl)hydroxylamine (DPPH), allows access to a broad scope of secondary amides bearing aromatic and olefinic groups, including enamides, α,β-unsaturated amides, and α,β-unsaturated enamides. Drug-like analogs can be rapidly assembled, and we show that "reverse amide" counterparts can be generated from the same starting materials.

PMID:
42418173
Bibliographic data and abstract were imported from PubMed on 08 Jul 2026.

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