Assessment of internal consistency reliability and concurrent validity of PROMIS^® dyspnea characteristics v1.0, PROMIS^® dyspnea functional limitations 10a, and PROMIS^® global health v1.2 in a dysautonomia cohort.

Authors

Andrew J Latham, John A O'Dell, Thanh Ho, Shelley Chavis, Silvia E Smith

Published in

Journal of patient-reported outcomes. Jul 08, 2026. Epub Jul 08, 2026.

Abstract

Dyspnea, or shortness of breath, is frequently reported among individuals with autonomic nervous system dysfunction, or dysautonomia. Currently, there are no validated dyspnea-specific patient-reported outcome measures for this population.
We conducted a patient-reported outcomes study to evaluate the internal consistency, reliability, and concurrent criterion-related validity of three PROMIS^® instruments: Dyspnea Characteristics v1.0, Dyspnea Functional Limitations 10a, and Global Health v1.2 in a cohort of adult individuals with dysautonomia. These instruments assess the prevalence of dyspnea, general quality of life, and dyspnea-related functional limitations.
Of the 617 participants enrolled in this study, 414 individuals without comorbid conditions causing dyspnea were included in the primary analysis. The PROMIS^® Dyspnea Characteristics v1.0 and PROMIS^® Dyspnea Functional Limitations 10a instruments demonstrated good to excellent internal consistency reliability (Cronbach's alpha = 0.896-0.909; McDonald's omega total = 0.911-0.912). The PROMIS^® Global Health v1.2 instrument demonstrated good overall internal consistency (Cronbach's alpha = 0.846, McDonald's omega total = 0.852), although reliability varied among the Global Physical Health and Global Mental Health summary scores (Cronbach's alpha = 0.640-0.759; McDonald's omega total = 0.664-0.767). Confirmatory factor analysis supported a unidimensional structure for both the PROMIS^® Dyspnea Characteristics v1.0 and Dyspnea Functional Limitations 10a instruments and a two-factor structure (Global Physical Health and Global Mental Health) for the Global Health v1.2 instrument. The indices demonstrated a good to excellent model fit (Comparative Fit Index = 0.983-1.00). Analyses demonstrated strong concurrent criterion-related validity for the PROMIS^® Dyspnea Functional Limitations 10a instrument (r = 0.59063) and weak-to-moderate concurrent validity for the Global Health v1.2 instrument (r = -0.17763 to -0.35034).
These findings support the use of the PROMIS^® Dyspnea Functional Limitations 10a and Global Health v1.2 instruments in clinical and research settings to assess symptom burden, functional limitations, and quality of life in adults with dysautonomia.

PMID:
42418144
Bibliographic data and abstract were imported from PubMed on 08 Jul 2026.

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