Authors
Pablo Mata-Martínez, Laura Bravo-Robles, Laura Hurtado-Navarro, Laura Córdoba, Julia Del Prado Montero, Francisco J Cueto, Karla Montalbán-Hernández, Jaime Fernández, Verónica Terrón-Arcos, Jose Ignacio Tudela, Mariana Tavecchia, Joaquín Fisac Vázquez, Rubén Fernández, Natalia González, Sylwia Anna Bilas, Rebeca Abad, Esteban Díaz, Aurora Burgos, Ramón Cantero-Cid, Eduardo López-Collazo, José Luis Subiza, Marcos Viñuela, Carlos Del Fresno
Published in
Scientific reports. Jul 09, 2026. Epub Jul 09, 2026.
Abstract
Non-invasive biomarkers for early detection and prognosis of colorectal cancer (CRC) remain an unmet clinical need. In this work, we investigated Ca10H, a novel circulating carbohydrate antigen, as a plasma biomarker with prognostic value in CRC. Plasma Ca10H was quantified by ELISA in a retrospective cohort of 448 individuals, including CRC patients (n = 301), patients with colorectal adenomas (n = 52), and healthy volunteers (n = 95). Ca10H levels were significantly elevated in CRC patients and were even higher in patients with adenomas, showing an inverse association with tumor progression. Importantly, baseline Ca10H levels were significantly higher in patients who survived compared with those who died during follow-up, both in univariate and multivariate analyses. Consistently, CRC patients with high plasma Ca10H levels exhibited improved disease-specific survival over an up to 10-year follow-up period, and Cox regression analysis confirmed high Ca10H levels as an independent positive prognostic factor (HR 0.592, 95% CI 0.428 - 0.819, p = 0.002). These findings highlight Ca10H as a promising non-invasive biomarker associated with a favorable prognosis in CRC, with strong potential for patient stratification and improving personalized management.
PMID:
42420361
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.
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