[Disseminated adenovirus infection complicating acute graft-versus-host disease: potential for early diagnosis by immunohistochemistry].

Authors

Ryo Yamashita, Shuhei Kurosawa, Yu Naito, Yuho Najima, Atsushi Wada, Takashi Hamamura, Naoki Shingai, Takashi Toya, Tomomi Toubai, Kaoru Morita, Hiroaki Shimizu, Kyoko Haraguchi, Toru Motoi, Tsunekazu Hishima, Noriko Doki

Published in

[Rinsho ketsueki] The Japanese journal of clinical hematology. Volume 67. Issue 6. Pages 542-546.

Abstract

A 30-year-old man underwent his third allogeneic hematopoietic stem cell transplantation for relapsed B-lymphoblastic leukemia. Watery diarrhea appeared on post-transplant day17, and colonoscopy on day21 revealed acute graft-versus-host disease (GVHD). The disease was refractory to steroid therapy, and hepatocellular injury progressed on day26. The patient died of multiple organ failure on day29. Autopsy demonstrated adenovirus (ADV) infection in the liver and colon, and the plasma ADV DNA load immediately before death was 3.16×10⁹ copies/ml, consistent with disseminated ADV infection. Re-evaluation of the colonic biopsy on day21 revealed not only histological features consistent with GVHD but also positive staining for ADV antigens in the intestinal epithelium. At autopsy, ADV had spread from the intestinal epithelium to the vascular endothelium. These findings suggest that immunohistochemistry in high-risk post-transplant patients may enable earlier detection of ADV infection.

PMID:
42419984
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.