Association of GBA1 status and sex with depression severity and progression in Parkinson's disease.

Authors

Pierfrancesco Mitrotti, Micol Avenali, Carlo Alberto Artusi, Rosa De Micco, Giulia Giannini, Rosaria Calabrese, Luca Gallo, Caterina Galandra, Claudia Ledda, Alice Mascia, Mattia Siciliano, Francesco Pagliuca, Luisa Sambati, Valeria Sant'Elia, Gianfranco Vornetti, Giovanna Calandra-Buonaura, Leonardo Lopiano, Raffaele Lodi, Alessandro Tessitore, Marco Bozzali, Enza Maria Valente

Published in

NPJ Parkinson's disease. Jul 08, 2026. Epub Jul 08, 2026.

Abstract

GBA1 variants increase neuropsychiatric vulnerability in Parkinson's disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.

PMID:
42420305
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

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