Plasma microbial cell-free DNA sequencing for detection of Coxiella burnetii aortic endograft infection with vertebral osteomyelitis.

Authors

Ashita Jain, Sarwat Khalil, Muhammad R Sohail, Ahmed Hamdi, Todd Lasco, Ayman A Farag, Mayar Al Mohajer

Published in

Antimicrobial stewardship & healthcare epidemiology : ASHE. Volume 6. Issue 1. Pages e203. Epub Jul 06, 2026.

Abstract

Chronic Q fever can present as culture-negative aortic endograft infection with osteomyelitis. Plasma microbial cell-free DNA sequencing unexpectedly detected Coxiella burnetii before serology, prompting exposure reassessment and targeted therapy. Later operative cultures grew Eikenella corrodens, underscoring the need to pair molecular results with serology and source-control microbiology.

PMID:
42422869
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

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