Authors
Sacide Pehlivan, Yasemin Oyaci, Naci Şenkal, Ebru Teberik Kama, Mustafa Pehlivan, Tufan Tükek, Alpay Medetalibeyoğlu
Published in
Epigenomics. Pages 1-9. Jul 09, 2026. Epub Jul 09, 2026.
Abstract
Metabolic syndrome (MetS) is a complex condition characterized by multiple metabolic abnormalities, in which epigenetic regulation has been increasingly implicated. This study aimed to evaluate global DNA methylation markers, 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC), in individuals with MetS and examine their associations with clinical and biochemical parameters.
A total of 200 patients with MetS and 103 healthy controls were included. Global 5-mC and 5-hmC levels were compared between groups. In the MetS group, correlations between these markers and metabolic, renal, and endocrine parameters were assessed using Spearman correlation analysis.
Global 5-mC levels were significantly higher in MetS patients than in controls (p < 0.001), whereas global 5-hmC levels did not differ between groups. However, 5-hmC levels were negatively correlated with body weight, glycated hemoglobin (HbA1c), triglycerides, creatinine, and thyroid-stimulating hormone (TSH), and positively correlated with high-density lipoprotein cholesterol (HDL-C) and free thyroxine (free T4). In contrast, 5-mC levels showed limited associations with clinical parameters.
Global 5-mC levels are elevated in MetS, whereas 5-hmC levels remain unchanged. The broader associations of 5-hmC with clinical and biochemical parameters suggest that hydroxymethylation may provide complementary insight into metabolic heterogeneity in MetS.
PMID:
42423069
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.
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