Phase Angle Shows a Negative Correlation With Serum GDF-15 Concentrations in Hospitalized Patients With Cardiovascular Disease.

Authors

Taira Fukuda, Kan Kondo, Riichi Nishikawa, Rina Hirai, Hayato Ishizaka, Hideaki Tan, Naohiro Nozawa, Seiko Tokoi, Suguru Hirose, Suomi Yamaguchi, Hiroshi Yagi, Takuo Arikawa, Hirohisa Amano, Masashi Sakuma, Ikuko Shibasaki, Hirotsugu Fukuda, Shigeru Toyoda, Toshiaki Nakajima

Published in

Journal of nutrition and metabolism. Volume 2026. Pages 3379141. Epub Jul 08, 2026.

Abstract

Growth differentiation factor (GDF)-15 is associated with various conditions such as cardiovascular disease, inflammation, and chronic kidney disease. Phase angle (PhA) reflects cellular health and nutritional status. However, the relationship between serum GDF-15 concentrations and PhA is unclear.
Serum GDF-15 concentrations in patients with heart failure (n = 91), aortic stenosis patients undergoing aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI) (n = 48), and healthy older individuals (n = 73) were measured via enzyme-linked immunosorbent assay. PhA was measured with an impedance-based body composition analyzer.
PhA showed a negative correlation with serum GDF-15 concentrations in total subjects. PhA showed a positive correlation with serum albumin (Alb) levels, hemoglobin (Hb) levels, estimated glomerular filtration rate (eGFR), and grip strength, and serum GDF-15 concentrations showed a negative correlation with serum Alb levels, Hb levels, eGFR, and grip strength. In multivariate regression analysis, after adjusting for age, PhA reflected the association with grip strength. For the presence or absence of muscle weakness measured by handgrip strength, in men, PhA had a cutoff value of 4.35 and an area under the curve (AUC) of 0.857, while GDF-15 had a cutoff value of 2012 pg/mL and an AUC of 0.773. In women, PhA had a cutoff value of 4.25 and an AUC of 0.804, while GDF-15 had a cutoff value of 1109 pg/mL and an AUC of 0.764.
PhA showed a negative correlation with serum GDF-15 concentrations in hospitalized patients with cardiovascular disease. Both PhA and serum GDF-15 concentrations might be considered as a biomarker of sarcopenia or cachexia.

PMID:
42422863
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.