Interleukin-8 in health and disease.

Authors

Chiara Bazzichetto, Emanuela Dell'Aquila, Margherita Veroli, Lorenzo Belluomini, Adele Bonato, Giovanni Bernardini, Michele Bevilacqua, Filippo Cattazzo, Andrea Dalbeni, Tarcisio Michele Tampu, Valentina Salari, Paolo Francesco Fabene, Claudio Luchini, Michele Milella, Fabiana Conciatori

Published in

Molecular biomedicine. Volume 7. Issue 1. Jul 09, 2026. Epub Jul 09, 2026.

Abstract

Cytokines are among the main factors involved in indirect cell-to-cell communication in physiological and pathological conditions. In this way, cytokines are soluble and tissue-resident easily detectable biomarkers for the diagnosis and the prediction of clinical outcome, as well as drug targets. Over the years, the pleiotropic IL-8 gained a central role in the pathogenesis of several immunological disorders, spanning from autoimmune pathologies and sepsis to neurological, liver and cardiovascular diseases. In several solid cancers, IL-8 not only serves as a prognostic biomarker but also as predictive tool. Increasing evidence highlighted IL-8 as a prognostic/predictive biomarker even for immunotherapy to stratify eligible patients, to avoid unnecessary toxicity and progression. Today, a comprehensive review covering IL-8 in all these fields has not yet been published. Hence, we aim to provide preclinical and clinical evidence on the biology and functions of IL-8, involved in the pathogenesis of non-malignant diseases, including inflammatory bowel diseases, sepsis, neuroinflammation, liver and cardiovascular pathologies. In oncology area, we will describe the pro-tumorigenic roles, including the characterization of the immunosuppressive microenvironment, also discussing the implications of direct/indirect IL-8 targeting and the involvement of gut microbiota. Unfortunately, the main obstacles to establish IL-8 as a useful non-invasive clinical tool for diagnosis and treatments' selection are the lack of the standardization of method detection and the source of IL-8 production.

PMID:
42423773
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

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