Authors
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen
Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e76381. Jul 09, 2026. Epub Jul 09, 2026.
Abstract
Endocrine-disrupting chemicals (EDCs) are pervasive environmental chemicals affecting hormone homeostasis, yet mapping mixture exposures to mechanisms at the population scale remains challenging. Here, analyses of 4255 U.S. participants are integrated with computational and experimental validation, linking population signals to molecular targets. Profiling 37 EDCs reveals consistent associations between phthalate metabolites and lower testosterone, strongest in adult males. Mono-(3-carboxypropyl) phthalate (MCPP) is identified as a key disruptor and is shown to inhibit CYP17A1, consistent with engagement of the enzyme's iron-protoporphyrin IX (heme) center. Docking/molecular dynamics prioritizes this interaction, which is supported by surface plasmon resonance, multi-matrix metabolomics in vivo and in vitro, and functional assays in primary Leydig cells. An interactive web resource (https://chembio.njmu.edu.cn/edc-hormone-explorer.html) provides open access to the association landscape and supports risk prioritization.
PMID:
42423525
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.
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