Authors
Cesar Rodrigo Arce-Sandoval, Adolfo Calderon-Fernández, Francisco Baltazar-Jimenez, Jorge Eduardo Cortes-Arroyo, Jose de Jesus Nuño-Pulido, Jose Carlos Campos-Barba, Maryuri Dorita Chumbes-Aguirre, Juan Jose Parcero-Valdes
Published in
JACC. Case reports. Pages 109198. Jul 09, 2026. Epub Jul 09, 2026.
Abstract
A 31-year-old woman presented with progressive dyspnea, orthopnea, cough, fatigue, and marked weight loss. Multimodality imaging demonstrated metastatic pancreatic malignancy with malignant pericardial effusion, a contrast-enhancing left ventricular apical mass, and right ventricular pressure overload. Contrast-enhanced computed tomography revealed extrinsic compression of the right pulmonary artery by mediastinal lymphadenopathy, causing functional supravalvular stenosis. She developed tamponade physiology, obstructive shock, and renal dysfunction; palliative discharge was agreed on after discussion.
Malignant pulmonary artery compression is a rare mimic of pulmonary embolism and may present with unexplained right ventricular failure in patients with advanced cancer.
In patients with cancer with unexplained right ventricular failure, malignant pulmonary artery compression should be considered. Multimodality imaging distinguishes this entity from pulmonary embolism or pulmonary hypertension.
PMID:
42423573
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.
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