The Impact of Exercise Tolerance Assessed by 6-Min Walking Distance on Clinical Outcomes in Patients With Interstitial Lung Disease Associated With Connective Tissue Diseases.

Authors

Hidenori Kariya, Kenji Oku, Yoshikazu Suzuki, Yohei Yamato, Shuken Kobayashi, Kunihiro Yamaoka

Published in

International journal of rheumatic diseases. Volume 29. Issue 7. Pages e70765.

Abstract

This study aimed to determine whether exercise tolerance assessed by 6-min walk distance (6MWD) predicts clinical outcomes in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).
This was an ambispective cohort study. We included patients in a stable condition with CTD-ILD. The 6MWD during hospitalization was used to determine the exercise tolerance. The primary endpoint was all-cause mortality, and the secondary endpoint was hospitalization for pulmonary disease. We examined the association between the 6MWD and each endpoint.
Among the 224 patients evaluated {median age 66.5 [interquartile range (IQR) 55.0-74.0] years; 146 females}, there were 23 deaths and 56 hospitalizations for pulmonary disease during the median follow-up period of 1.2 (IQR 0.6-2.3) years. The 6MWD of 310 m and 260 m were identified as optimal cut-off points for the prediction of all-cause mortality and hospitalization for pulmonary disease, respectively. The Kaplan-Meier survival curve showed that a higher 6MWD was associated with a lower rate of all-cause mortality and hospitalization for pulmonary disease (log-rank = 16.146, p < 0.001 and log-rank = 9.065, p = 0.003, respectively). After adjusting for clinical confounding factors, the hazard ratios for all-cause mortality and hospitalization for pulmonary disease per 10-m increase in 6MWD were 0.962 [95% confidence interval (CI): 0.927-0.998] and 0.968 (95% CI 0.946-0.991), respectively.
Higher exercise tolerance, as assessed by 6MWD, was independently associated with a better prognosis in stable patients with CTD-ILD.

PMID:
42423508
Bibliographic data and abstract were imported from PubMed on 09 Jul 2026.

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