Authors
Wenbo Ji, Yaxu Yang, Xinyi Cao, Jie Song, Zhenhai Zhang, Huixia Lv
Published in
The Journal of pharmacy and pharmacology. Volume 78. Issue 7. Jul 03, 2026.
Abstract
To develop a gelatin methacrylate hydrogel dressing loaded with traditional Chinese medicine active components-resveratrol (RES), 18-β-glycyrrhetinic acid (GA), and berberine (BBR)-for the treatment of infected wounds, aiming to enhance wound healing through their anti-inflammatory, antibacterial, and antioxidant properties.
Methacrylamidated gelatin was synthesized from gelatin and methacrylic anhydride and used to load RES, GA, and BBR. The wound-healing and anti-infective effects were evaluated in a mouse model with full-thickness dorsal skin defects. Histological evaluation was performed via hematoxylin and eosin staining to assess re-epithelialization and hair follicle regeneration.
Gelatin methacrylate hydrogel dressings loaded with RES, 18-GA, or BBR alone showed therapeutic effects in clearing infection and promoting healing. Gelatin methacrylate hydrogel dressings co-loaded with RES, GA, and BBR achieved a wound closure rate of 77.92% by Day 12. The triple-loaded dressing demonstrated higher infection clearance, more continuous epidermis, and increased hair follicle regeneration compared with single-component dressings.
Gelatin methacrylate hydrogel dressings co-loaded with RES, GA, and BBR exhibit superior potential in promoting the healing of infected wounds, as evidenced by enhanced wound closure, infection clearance, and skin structure regeneration in vivo.
PMID:
42424602
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.
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