Impact of Adjuvant Radiotherapy on Recurrence Outcomes in pT2N0 Oral Squamous Cell Carcinoma: A Propensity Score-Matched Survival Analysis.

Authors

Hemant Nemade, Abhinav Thaduri, Jonathan T Gondi, Sravan Kumar Chava, Anil Kumar Akula, Abhilash Konkimalla, Daphne Fonseca, Sahithi Shilpa Arya, Deleep Kumar Gudipudi, Ashwini Gopal, L M Chandra Sekara Rao S

Published in

Head & neck. Jul 09, 2026. Epub Jul 09, 2026.

Abstract

The benefit of adjuvant radiotherapy in pT2N0 oral squamous cell carcinoma (OSCC) remains uncertain. We evaluated its impact on disease-free survival (DFS) using propensity score matching.
Patients with pT2N0 OSCC treated between 2015 and 2023 were identified from a prospectively maintained database. One-to-one nearest-neighbor propensity score matching was performed using age, tumor size, depth of invasion, perineural invasion, lymphovascular invasion, margin distance, tumor subsite, histological grade, and bilateral neck dissection status. Three-year DFS was analyzed using Kaplan-Meier methods and Cox regression.
Among 400 eligible patients, 226 underwent surgery alone, and 174 received adjuvant radiotherapy. Propensity score matching generated 107 matched pairs. Three-year DFS was 78.3% for surgery alone and 82.1% for surgery plus radiotherapy (p = 0.41). Adjuvant radiotherapy was not associated with improved DFS (HR 0.81, 95% CI 0.48-1.30; p = 0.43).
In this propensity score-matched cohort, adjuvant radiotherapy was not associated with improved 3-year DFS in pT2N0 OSCC.

PMID:
42425923
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.

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