Authors
Mingyue Ding, Bingyu Qin
Published in
The Journal of international medical research. Volume 54. Issue 7. Pages 3000605261459294. Epub Jul 09, 2026.
Abstract
ObjectiveTo investigate the association between the high-sensitivity C-reactive protein-to-hemoglobin ratio and stroke risk among middle-aged and older adults.MethodsA prospective follow-up study was conducted using cohort data from the China Health and Retirement Longitudinal Study (CHARLS) and the English Longitudinal Study of Ageing (ELSA). Participants without a history of stroke at baseline were included, comprising 5368 individuals from CHARLS and 1422 from ELSA. Cox proportional hazards regression models were used to analyze the association between C-reactive protein-to-hemoglobin ratio levels and stroke risk, along with dose-response analyses and subgroup interaction testing.ResultsAfter adjusting for sex, age, lifestyle factors, and multiple clinical biochemical indicators, the participants in Q2, Q3, and Q4 demonstrated a significantly higher risk of stroke than those in Q1 (reference group). The hazard ratios were 2.23 (1.35-3.69), 2.24 (1.36-3.71), and 3.14 (1.93-5.12), respectively (all P < 0.01). Dose-response analysis revealed an approximately linear positive association between C-reactive protein-to-hemoglobin ratio and stroke risk.ConclusionsC-reactive protein-to-hemoglobin ratio levels are significantly and positively associated with stroke risk in middle-aged and older adults.
PMID:
42426571
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 4
- Comments 0