Authors
Bingyan Zhu, Yuling Chen, Yuntao Lin, Tingting Luo, Hongyu Yang, Bo Lin
Published in
International journal of nanomedicine. Volume 21. Pages 606614. Epub Jul 03, 2026.
Abstract
Conventional physical interventions, including static photothermal ablation, frequently fail to eradicate cancer stem cells (CSCs) and instead induce sublethal stress that promotes therapeutic resistance. To address this translational challenge, this review establishes a comprehensive framework utilizing engineered gold nanoplatforms to advance the treatment strategy from non-specific cytotoxicity toward mechanism-driven phenotypic reprogramming. We outline how stimuli-responsive surface functionalization helps resolve the size-permeability paradox to secure precise intracellular access. Upon internalization, these platforms suppress intrinsic defenses by intercepting morphogenic pathways, inducing mesenchymal-to-epithelial transitions, and disrupting the bioenergetic dependence of multidrug resistance. Following this phenotypic stabilization, gold nanostructures catalyze targeted cell death via ferroptotic redox disruption and dual-metabolic blockade, alongside the immunological remodeling of the tumor microenvironment. Ultimately, by integrating real-time metabolic feedback with macroscopic surveillance, this strategy highlights the potential of gold nanoplatforms as adaptive, responsive systems to achieve precision therapy and overcome CSC-driven relapse.
PMID:
42428967
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.
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