From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease.

Authors

Van Dung Nguyen, Bisheng Zhou

Published in

Pulmonary circulation. Volume 16. Issue 2. Pages e70287. Epub Mar 30, 2026.

Abstract

Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders. Therefore, targeting endothelial cells could hold promising therapeutic strategies for preventing disease development. Although significant advances in technology have revolutionized our understanding of endothelial heterogeneity and plasticity, effective and curative treatment options remain limited. Here, we discuss the molecular and functional diversity of lung endothelial cells and their critical role in maintaining lung homeostasis and in lung pathologies. We also briefly describe advanced technologies, such as single-cell RNA sequencing and spatial transcriptomics, to uncover complex cell communication and underlying mechanisms. Furthermore, this review will identify future research questions for developing therapeutic approaches targeting lung endothelial cells.

PMID:
42428584
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.