Authors
Pan Wang, Meng Gan, Liuyang Chen, Lixin Du, Zujun Hou, Cong Wang, Fan Lin
Published in
Frontiers in human neuroscience. Volume 20. Pages 1794651. Epub Jun 25, 2026.
Abstract
To evaluate the advantages of 5T magnetic resonance imaging (MRI) in dynamic susceptibility contrast (DSC) analysis for brain imaging and explore whether standardized perfusion parameters show similar distributions between 3T and 5T cohorts.
Retrospective analysis of 52 adults undergoing 3T/5T MRI (July 2022-February 2025) with T1-weighted and DSC-MRI sequences. Perfusion parameters [cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT)] and gray matter-to-white matter (GM/WM) ratios were quantified using MItalytics software. Signal-to-noise (SNR) and contrast ratios (CR) were compared, with Wilcoxon rank-sum tests.
Fifty-two patients (male/female: 24/28; age range: 24-74 years) were divided into 3T (n = 23) and 5T (n = 29) cohorts. In T1-weighted imaging, 3T demonstrated significantly higher SNR (p < 0.001), while 5T exhibited superior CR. For DSC-MRI, 5T achieved SNR comparable to 3T despite shorter repetition time (TR) and echo time (TE). No significant differences in perfusion parameters (CBV, CBF, MTT) were observed between field strengths. GM/WM ratios showed strong concordance: CBV ratios were 2.060 ± 0.223 (3T) vs. 2.062 ± 0.176 (5T), and CBF ratios were 1.985 ± 0.236 (3T) vs. 1.996 ± 0.173 (5T).
In this retrospective analysis, 5T MRI showed higher T1-weighted contrast and similar DSC-MRI SNR relative to 3T under the tested protocols. DSC perfusion parameters, quantified using the MItalytics platform, showed no statistically significant between-cohort differences.
PMID:
42428963
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.
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