Meroterpenoids Isolated from Avicennia marina Fruit Fungal Strain Aspergillus sp.

Authors

Fan-Fan Wang, Xiaoxia Liu, Xuefeng Jin, Jing-Jing Tao, Ji-Wen Wu, Li-Ping Mo, Pingfang Tao, Xin-Xiu Nong, Feng Qin, Zhongqing Wen

Published in

ACS omega. Volume 11. Issue 26. Pages 38450-38456. Jul 07, 2026. Epub Jun 25, 2026.

Abstract

3 new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes R-T (1-3), one new natural product (9), and six known compounds (4-8 and 10), were obtained from Avicennia marina (Forssk.) Vierh. fruit fungal strain Aspergillus sp. YLNU-Q11. These new compounds' structures were elucidated using spectroscopic analyses, NMR/DP4+ calculations, and ECD studies. In the acetylcholinesterase (AChE) inhibitory assay, compound 8 showed moderate inhibitory activity (IC₅₀ = 9.54 μM). Further molecular docking analysis suggested that hydrogen bonding interactions with residues TYR374, GLY79, and GLY150 are crucial for the binding of 8 to AChE.

PMID:
42428885
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.

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