Pasireotide induces proteins related to autophagy in cancer cells.

Authors

Madan Sigdel, Saikat Fakir, Md Matiur Rahman Sarker, Nektarios Barabutis

Published in

Endocrine. Volume 91. Issue 1. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

To investigate the possibility that Pasireotide (PAS), which is a synthetic somatostatin analog (SSA), induces proteins related to autophagy in cancer cells.
MDA-MB-468 and HeLa human cancer cells were exposed to PAS or vehicle for 8, 24 and 32 h, to assess possible effects in autophagy-related proteins. Western blot analysis was utilized to assess changes in protein expression levels due to PAS exposure.
PAS treatment induces the expression of the autophagy-related protein (ATG)-3, ATG-7, and Beclin-1 in MDA-MB-468 and HeLa cells.
Our findings suggest that the beneficial effects of PAS in cancers may involve autophagy. Further studies will attempt to elucidate the underlying mechanisms mediating those effects.

PMID:
42429880
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.

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