Authors
Mohid Zulfiqar, Muhammad Salik Uddin, Faizan Abbas, Asim Sajjad, Ammad Uddin, Syed Ahmed Ali Shah, Gregg C Fonarow, Saad Ahmed Waqas, Hermann Yokolo, Shaheer Qureshi
Published in
Alcohol, clinical & experimental research. Volume 50. Issue 7. Pages e70321.
Abstract
Alcohol consumption is a leading cause of preventable mortality worldwide. We examined long-term trends in alcohol-related deaths in the United States over 55 years (1968-2023) and analyzed demographic disparities.
Using CDC WONDER data, we identified alcohol-related deaths among adults aged ≥ 25 years. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated, and joinpoint regression analyzed temporal trends by sex, race, age, and geographic region.
From 1968 to 2023, 1,321,804 alcohol-related deaths occurred. AAMRs increased from 13.1 to 19.3 (AAPC: 0.7, p < 0.001), with a sharp acceleration during 2018-2021 (APC: 14.1) followed by a decline during 2021-2023 (APC: -6.9). Males consistently had higher mortality than females, though the gender gap narrowed. A striking racial inversion occurred: mortality among Black individuals declined from 27.7 to 13.5 (AAPC: -1.4), while mortality among White individuals increased from 11.3 to 21.1 (AAPC: 1.1) with older adults (65+) showing the steepest long-term increase (AAPC: 1.4). Regionally, the Midwest experienced the greatest rise in mortality (AAPC: 1.4), while the Northeast remained stable.
Alcohol-related mortality has increased substantially over 55 years, with profound demographic shifts including a complete racial disparity inversion and narrowing gender gap. Recent declines (2021-2023) offer cautious optimism, but sustained, targeted interventions are needed for high-risk populations.
PMID:
42429647
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.
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