Twenty-five years of human metapneumovirus research.

Authors

Elhadji Birane Mboup, Julia Dubois, Marie-Ève Hamelin, Manuel Rosa-Calatrava, Guy Boivin

Published in

Clinical microbiology reviews. Pages e0033025. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

SUMMARYThe year 2026 marks the 25th anniversary of the discovery of human metapneumovirus (HMPV), which belongs to the metapneumovirus genus within the Pneumoviridae family. The respiratory syncytial virus (RSV), discovered in 1956, is a close relative of HMPV belonging to the same family but to a different genus. In this article, we review key past findings related to HMPV infection, highlighting the differences with RSV. In addition, we specifically discuss current research areas pertaining to changing epidemiology, clinical burden, host response, as well as therapeutic and prophylactic modalities now in clinical trials. Additional research on HMPV is needed to contain this important respiratory virus.

PMID:
42429631
Bibliographic data and abstract were imported from PubMed on 10 Jul 2026.

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