Selenized Polysaccharides Exert Immunotherapy Enhancement by Reprogramming Macrophage Polarization: A Comparative Study of Selenium Forms.

Authors

Xiaoyan Jia, Zhuofan Wang, Ziyu Liu, Yunyi Zhang, Wenyu Zhang, Shengyong Zhu, Xiaoxiao Liu, Li Li, Jiayin Dong, Yibo Xian, Shen Song, Ji Zhang, Junlong Wang

Published in

Journal of agricultural and food chemistry. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

Macrophage repolarization from M2 to M1 is a promising strategy for immunomodulatory functional foods. Here, Artemisia sphaerocephala polysaccharide was structurally characterized, and selenized ASPs with controllable selenium (Se) contents and molecular masses were prepared using a dissolution-enhanced magnetic solid acid-catalyzed strategy. Compared with Na₂SeO₃ and selenium nanoparticles (SeNPs) under Se-equivalent conditions, high-Se SeASP_H more effectively promoted M1-like macrophage polarization, as shown by increased CD86, decreased CD206, enhanced proinflammatory cytokine production, and MAPK/NF-κB activation. Conditioned medium from SeASP-reprogrammed macrophages inhibited B16 melanoma cell migration and induced mitochondrial apoptosis through regulation of CXCL12 and apoptosis-related proteins. In B16 melanoma-bearing mice, SeASP_H suppressed tumor growth, increased F4/80⁺CD86⁺ signals, reduced F4/80⁺CD206⁺ signals, and enhanced tumor apoptosis without obvious systemic toxicity. These results support SeASP_H as a promising organic Se-enriched polysaccharide for developing immunomodulatory functional food components.

PMID:
42430500
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

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