Authors
Shiman Hu 胡诗曼, Jiaxian Liu, Jiaqi Zhou, Jiaohua Chen, Tiantian Qin, Yi Ching Esther Wan, Xiaoxuan Zhu, Danyi Wang, Chuting Shao, Yabin Chen, Xin Wang, Junhong Han, Hoi Leong Xavier Wong, Robert S Weiss, Haojie Jin, Mo Chen, Qing Li, Yogen Saunthararajah, Haiyun Gan, Kui Ming Chan 陈居明
Published in
Science advances. Volume 12. Issue 28. Pages eadx4982. Jul 10, 2026. Epub Jul 10, 2026.
Abstract
Cancer progression is driven by the accumulation of DNA mutations and aberrant gene regulation. Recent studies have demonstrated that multiple H3 mutations serve as drivers of tumorigenesis. However, the role and significance of various cancer-associated histone H2B mutations in cancer development remain unknown. Here, we investigate H2BE113K, a missense mutation of histone H2B predominantly found in patients with breast cancer. We show that H2BE113K promotes colony formation in breast cancer. Notably, transcriptomic analysis reveals differential expression of genes in various cancer pathways in H2BE113K cells. The loci with elevated gene expression display increased chromatin accessibility, accompanied by H2BE113K enrichment. Depletion of G3BP2, one of the H2BE113K target genes that has been implicated in breast cancer, reduces the colony formation phenotype in H2BE113K cells. In addition, H2BE113K knock-in mice crossbred with an MMTV-PyMT breast cancer model show elevated lung metastasis. Together, our findings provide critical insights in the mechanistic role of H2BE113K in gene regulation, chromatin function, and breast cancer progression.
PMID:
42430466
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.
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