Calcitriol Suppresses Platelet Activation and Thrombosis, Mitigating Cardiovascular Risks in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Authors

Peng Zhang, Huajie Xu, Shujing Wu, Wenxuan Zhou, Luning Zhou, Liping Han, Wei Zhang, Xiaoyu Lian, Xin Zhao, Haoxuan Zhong, Bing Fan, Hongyi Wu, Zhiyong Qi

Published in

JACC. Basic to translational science. Volume 11. Issue 8. Pages 101632. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

Metabolic dysfunction-associated steatotic liver disease is associated with vitamin D deficiency, and platelets exhibit hyperactivity. Zhang et al provide novel insights into the mechanisms underlying platelet hyperreactivity and thrombotic risk in patients with metabolic dysfunction-associated steatotic liver disease, demonstrating that calcitriol activates the vitamin D receptor in megakaryocytes and platelets, leading to the downregulation of P2Y₁₂ expression and the modulation of the cyclic adenosine monophosphate/protein kinase A and mitogen-activated protein kinase signaling pathways, thereby attenuating platelet activation.

PMID:
42430854
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

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