Antidiabetic activity of Cassia javanica flowers through in vitro inhibitory evaluation of α-amylase, α-glucosidase and its antiglycation property.

Authors

Íngrede Ferreira Silva, Tarcísio Paiva Mendonça, Matheus Cesar Rodrigues Garcia, Gáveni Barbosa Valério, Allisson Benatti Justino, Foued Salmen Espindola, Amanda Danuello, Marcos Pivatto

Published in

Natural product research. Pages 1-8. Jul 10, 2026. Epub Jul 10, 2026.

Abstract

Diabetes is a group of metabolic diseases that affect millions of people globally. Cassia javanica L. (Fabaceae), a tree native to Asia and present in Brazil, is used in folk medicine to treat diabetes and as a laxative. We evaluated the in vitro antidiabetic potential of ethanol extract, fractions and compounds isolated from the plant's flowers. The extract underwent liquid-liquid extraction with hexane, dichloromethane (FDCj) and ethyl acetate. FDCj showed activity against pancreatic α-amylase (IC₅₀ 0.3 μg mL^-1, triticum: 0.2 μg mL^-1), α-glucosidase (58.6%, acarbose: 98.6%) and strong antiglycation activity (>94.6%). Chromatography allowed the isolation of kaempferol, rhein, engeletin and afzelin, showing antiglycation activity (62.6-100%) and kaempferol stood out in inhibiting α-amylase (IC₅₀ 0.04 μg mL^-1). The results corroborate the traditional use of C. javanica in the treatment of diabetes and are the first study with biological activity of compounds isolated from this species.

PMID:
42430509
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

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