Comparison of preoperative urinary Titin levels and serum Titin levels in patients with gastrointestinal malignancy.

Authors

Mitsugi Shimoda, Kihiro Izumi, Masahiro Shiihara, Mitsuru Watanabe, Ryoichi Miyamoto, Jiro Shimazaki, Shuji Suzuki

Published in

Journal of gastrointestinal oncology. Volume 17. Issue 3. Pages 146. Jun 30, 2026. Epub May 14, 2026.

Abstract

In recent years, reports using urinary Titin (U-Titin) levels to evaluate patients with muscular dystrophy, myocardial infarction, myasthenia gravis, gastrointestinal malignancy (GIM), chronic liver disease, and sarcopenia have been sporadically observed; however, reports using serum Titin (S-Titin) levels are scarce. We report here on the measurement of S-Titin, which has now become feasible.
This study included 104 patients who underwent surgery for the diagnosis of GIM in our department between May 2024 and November 2025. Preoperative S-Titin and U-Titin levels were measured to investigate their correlation. Furthermore, using InBody, we measured skeletal muscle mass index (SMI), percent body fat (PBF), fat mass index (FMI), extracellular water (ECW)/total body water (TBW) and whole-body phase angle (Ph A) to investigate the relationship with S-Titin and U-Titin.
There were 28 female and 76 male patients, with a median age of 68 (range, 54-89) years. Location of malignant diseases was as follows: 42 cases of hepatobiliary-pancreatic cancer, 36 cases of colorectal cancer, and 26 cases of upper gastrointestinal cancer. S-Titin and U-Titin levels showed a strong positive correlation (r=0.78, y=0.19x+1.40, P<0.001). PBF, FMI, and Ph A showed a weak negative correlation with both levels, while ECW/TBW showed a weak positive correlation, however, no correlation was observed with SMI.
This study suggests that S-Titin levels, like U-Titin levels, may serve as a potential biomarker for skeletal muscle and nutritional disorders in GIM patients.

PMID:
42434266
Bibliographic data and abstract were imported from PubMed on 11 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.